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Intradermal penicillin skin test is more likely to be positive compared to prick skin test in patients with a history of penicillin allergy

Background Penicillin skin testing (PST) with the major determinant (benzyl-penicilloyl) and minor determinant mix (penicillin G, benzyl-penicilloate, and benzyl-penilloate) is one of the major diagnostic tools in the evaluation of a penicillin allergy mediated by IgE. The PST begins with a skin prick test (SP) with the above components and, if negative, then proceeds to an intradermal testing ...

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Benzyl Penicillin

The search for an orally administered and stable penicillin preparation with high therapeutic efficacy led to the recent discovery that the benzyl ester of penicillin, given orally, was at least equal in protective effect to the equivalent weight of sodium penicillin administered parenterally to mice that had received lethal doses of pneumococci and hemolytic streptococci by intraperitoneal inj...

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Oral Amoxicillin Versus Benzyl Penicillin for Severe Pneumonia Among Kenyan Children: A Pragmatic Randomized Controlled Noninferiority Trial

BACKGROUND There are concerns that the evidence from studies showing noninferiority of oral amoxicillin to benzyl penicillin for severe pneumonia may not be generalizable to high-mortality settings. METHODS An open-label, multicenter, randomized controlled noninferiority trial was conducted at 6 Kenyan hospitals. Eligible children aged 2-59 months were randomized to receive amoxicillin or ben...

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Diagnosing penicillin allergy in the absence of minor determinant mixture

Background Penicillin allergy is a common presentation in allergy clinic. The diagnosis of immediate hypersensitivity is made using clinical history, skin testing, specific IgE levels and oral challenge. Skin testing is done using benzyl penicilloyl-polylysine (PPL) and a minor determinant mixture (MDM) consisting of penicillin byproducts. Although using PPL and MDM is considered first line for...

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تاریخ انتشار 2012